We see lots of people who have Autism. We have heard about such cases too from the internet and media in general. But did you know that Autism had been treated 100 years ago?
What is Autism?
Autism is a mental condition that could happen in early childhood. it is characterized by impaired social interactions and difficulty in using language and abstract concepts.
Commonly, parents notice it in the first two years of their children’s life. It occurs from four to five times more often in boys than girls.
The new effective treatment is old!
Currently, we can overcome this disease according to Dr. Robert Naviaux, only within one week and with one dose.
Dr. Naviaux is a scientist of the San Diego School of Medicine who is an expert in human genetics, inborn errors of metabolism, metabolomics, and mitochondrial medicine.
He is the discoverer of the cause of Alpers syndrome (the oldest Mendelian form of the mitochondrial disease) and the developer of the first DNA test to diagnose it.
He used a drug called suramin which was first developed in 1916. It is used as an anti-parasitic drug for, only, treatment of river blindness (onchocerciasis) and African sleeping sickness (trypanosomiasis).
The scientist pleased with the significant results of the trial, accordingly, he said, “After the single dose, it was almost like a release of a roadblock”. But, If the future studies show that there’s continued health benefits, this could be a game-changer for families with autism.”
Responding to the drug “suramin”
The autistic boys between the ages of five to fourteen have an incredible response to the drug. They improve after only one infusion within one week, as Dr. Naviaux recorded.
The Annals of Clinical and Translational Neurology published the following study:
First, He recruited a number of children.
He gave five of them suramin, and gave placebos to others, and put four non-verbal children, two of them are 6 years old and the other two are 14 years old.
Second, He observed them and found, within a week after one infusion, that the four-non-verbal said their first sentences of their lives. Naviaux told UC San Diego Health Website ” This did not happen in any of the children given the placebo.”
Scientists say that suramin is the only treatment can that inhibit extracellular ATP signaling in humans, then, it gives the cells in CDR cycle all-clear signal they need to continue with their normal environment.
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Dr. Naviaux’s theory about Autism
When Dr. Naviaux saw that results he made a theory, according to his experience.
He said that “there is a fundamental metabolic problem in all people with ASD — namely, that cells in affected people experience abnormal levels of something that Naviaux has termed the “cell danger response(CDR)”.
And explained that CDR happens when a cell responds to external stressors or toxins. He describes this process as the cell hardening its membranes, ceasing interaction with neighbors, and withdrawing into itself until the danger has passed.
Naviaux extracted from the theory that there is a relationship between the CDR and Autistic children. AS he believes that the CDR process gets stuck in children with autism and that it can permanently alter how the cells interact with their external environment.
When this happens in early child development it results in the development of autism and various other chronic childhood disorders. So, the trial aimed to “un-stick” the CDR cycle by suramin.
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Witnesses of Autistic’s parents:
A parent of a child in the study, happily, wrote: “Suramin produced the most dramatic improvement in autism symptoms that we have ever seen with anything we have tried,”.
“Nothing has come close to all the changes in language and social interaction and new interests that we saw after suramin,” said another.
John Rodakis, the founder and president of N of One: Autism Research Foundation, which supported the trial said, “We would have loved to have done a much larger trial, we just didn’t have the funding for it.”
Since the Naviaux got funds only by grassroots efforts and from autism parents and advocates. There are no formal funds.
Side effects of suramin:
Its action is temporary as children who took suramin showed improvement for only a short time, and, The children also experienced a rash.
Finally, Dr. Naviaum must get funds to complete his study, as Dr. Naviaux said “This work is new and this type of clinical trial is expensive. We did not have enough funding to do a larger study. And even with the funding, we had to go $500,000 in debt to complete the trial.”